SSc is a heterogeneous autoimmune CTD characterized by widespread vasculopathy, formation of autoantibodies and varying degrees of skin and major organ fibrosis [1, 2]. The life-threatening nature of this disease is well depicted by a 5-year mortality of 30 50% in a subset of patients with dcSSc and internal organ involvement. Despite the substantial research over the past decade, the aetiology...

Аll known species of Larinioides Caporiacco, 1934 are revised. Seven species are recognised, of which one is transferred from Araneus Clerck, 1757 as a new combination, Larinioides jalimovi (Bakhvalov, 1981) comb. n. The first description of a male of L. jalimovi is given. The following four new synonyms are proposed: Epeira gracilis Menge, 1878 syn. n. and Aranea dumetorum islandicola Strand, ...

http://www.sciencemag.org/cgi/content/full/314/5806/1757 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/314/5806/1757/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http:/...

STAT3-STAT3 dimerization, which involves reciprocal binding of the STAT3-SH2 domain to phosphorylated tyrosine-705 (Y-705), is required for STAT3 nuclear translocation, DNA binding, and transcriptional regulation of downstream target genes. Here, we describe a small molecule S3I-1757 capable of disrupting STAT3-STAT3 dimerization, activation, and malignant transforming activity. Fluorescence po...

Context. Numerical simulations predict the existence of old Tidal Dwarf Galaxies (TDGs) that would have survived several Gyr after the collision lying at their origin. Such survivors, which would by now have become independent relaxed galaxies, would be ideal laboratories, if nearby enough, to tackle a number of topical issues, including the distribution of Dark Matter in and around galaxies. H...

Multiple cell types involved in the regulation of angiogenesis express Wnt ligands. Although β-catenin dependent and independent Wnt signaling pathways have been shown to control angiogenesis, the contribution of individual cell types to activate these downstream pathways in endothelial cells (ECs) during blood vessel formation is still elusive. To investigate the role of ECs in contributing Wn...

, 1757 (2006); 314 Science et al. B. Andrei Bernevig Quantum Wells Quantum Spin Hall Effect and Topological Phase Transition in HgTe This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission...

Cell lines expressing the human metabotropic glutamate receptor subtype 5a (hmGluR5a) and hmGluR1b were used as targets in an automated high-throughput screening (HTS) system that measures changes in intracellular Ca2+ ([Ca2+]i) using fluorescence detection. This functional screen was used to identify the mGluR5-selective antagonist, SIB-1757 [6-methyl-2-(phenylazo)-3-pyridinol], which inhibite...